Life Sciences Institute, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Cell. 2010 Sep 3;142(5):672-4. doi: 10.1016/j.cell.2010.08.022.
The omega-3 fatty acids have anti-inflammatory and antidiabetic effects in humans. Now, Oh et al. (2010) demonstrate that the G protein-coupled receptor GPR120 is a receptor for omega-3 fatty acids on macrophages and fat cells. Activation of GPR120 by omega-3 fatty acids inhibits multiple inflammation cascades in macrophages and reverses insulin resistance in obese mice.
ω-3 脂肪酸在人体中有抗炎和抗糖尿病的作用。现在，Oh 等人（2010）证明，G 蛋白偶联受体 GPR120 是巨噬细胞和脂肪细胞上 ω-3 脂肪酸的受体。ω-3 脂肪酸激活 GPR120 可抑制巨噬细胞中多种炎症级联反应，并逆转肥胖小鼠的胰岛素抵抗。
