Institute of Medical Biology, A*STAR, 138648 Singapore, Republic of Singapore.
Cell. 2010 Sep 3;142(5):676-8. doi: 10.1016/j.cell.2010.08.021.
In a tour-de-force study, Kobayashi et al. (2010) describe the first viable rat-mouse chimeras and demonstrate that rat induced pluripotent stem (iPS) cells can rescue organ deficiency in mice. Rat iPS cells formed a fully functional pancreas when injected into mouse blastocysts lacking the Pdx1 gene required for pancreas formation.
在一项杰出的研究中，小林等人（2010 年）描述了首例可行的大鼠-小鼠嵌合体，并证明大鼠诱导多能干细胞（iPS 细胞）可以挽救小鼠的器官缺陷。当将大鼠 iPS 细胞注入缺乏形成胰腺所需的 Pdx1 基因的小鼠囊胚中时，大鼠 iPS 细胞形成了一个完全功能的胰腺。
