Department of Ocular Pathology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Br J Ophthalmol. 2011 Feb;95(2):284-7. doi: 10.1136/bjo.2009.177204. Epub 2010 Sep 2.
Expression of β-catenin in sebaceous cell carcinoma (SbCC) of the eyelid and its correlation with histopathological features.
48 cases of SbCC were analysed immunohistochemically using monoclonal β-catenin antibody and the results correlated with tumour size, histopathological differentiation, orbital invasion and pagetoid spread.
Cytoplasmic overexpression of β-catenin was seen in 66% cases of SbCC which correlated positively with tumour size, orbital invasion and pagetoid spread. This correlation was found to be significant in tumour size > 2 cm (p = 0.242). Nuclear staining was not observed in any of the cases.
Cytoplasmic overexpression of β-catenin was observed in the majority of the cases of SbCC of eyelid, and this correlated significantly with tumour size. The authors therefore hypothesise that β-catenin overexpression in SbCC of eyelid may be a result of Wnt/β-catenin pathway dysregulation. However, its role both in the development of sebaceous cell carcinoma of the eyelid as well as its prognosis needs to be explored further.
研究β-连环蛋白在眼睑皮脂腺癌（SbCC）中的表达及其与组织病理学特征的关系。
采用单克隆β-连环蛋白抗体对 48 例 SbCC 进行免疫组织化学分析，并将结果与肿瘤大小、组织病理学分化、眼眶侵犯和湿疹样扩散相关联。
66%的 SbCC 中观察到β-连环蛋白的细胞质过表达，与肿瘤大小、眼眶侵犯和湿疹样扩散呈正相关。这种相关性在肿瘤大小>2cm 时具有统计学意义（p=0.242）。未观察到任何病例的核染色。
眼睑 SbCC 中观察到大多数病例存在β-连环蛋白的细胞质过表达，且与肿瘤大小显著相关。因此，作者假设眼睑 SbCC 中β-连环蛋白的过表达可能是 Wnt/β-连环蛋白通路失调的结果。然而，其在眼睑皮脂腺癌的发生发展及其预后中的作用仍需进一步探讨。
