Wu Qingping, Dong Xiaohui, Zhang Jumei, Ye Yingwang, Xu Xiaoke, Yang Xiaojuan, Wu Kui
Guangdong Provincial Public Laboratory for Applied and New Technology of Microbiology and Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou 510070, China.
Wei Sheng Wu Xue Bao. 2010 Jul;50(7):841-6.
Enterobacter sakazakii is an important food-borne pathogen that causes life-threatening meningitis and necrotizing colitis in neonates and children. In 2008, Enterobacter sakazakii has been reclassified as five species in a new genus, Cronobacter gen. nov. within the Enterobacteriaceae. There is the variation in virulence between species in the new genus. OmpA of Cronobacter gen. nov. plays a critical role in attachment to their host cell and persistence within macrophages. Disruption of the tight junction significantly enhances the efficiency of invasion. Specific probiotic strains and their combinations counteract adhesion of Cronobacter gen. nov to intestinal mucus. At present, very limited information is available regarding the pathogenesis of Cronobacter gen. nov. Further detailed mechanism studies on the pathogenicity are warranted.
阪崎肠杆菌是一种重要的食源性病原体，可导致新生儿和儿童危及生命的脑膜炎和坏死性结肠炎。2008年，阪崎肠杆菌被重新分类为肠杆菌科中一个新属——克罗诺杆菌属（Cronobacter gen. nov.）中的五个种。新属中的不同种之间存在毒力差异。克罗诺杆菌属的外膜蛋白A（OmpA）在其与宿主细胞的黏附以及在巨噬细胞内的存活中起关键作用。紧密连接的破坏显著提高了侵袭效率。特定的益生菌菌株及其组合可对抗克罗诺杆菌属对肠道黏液的黏附。目前，关于克罗诺杆菌属的发病机制的信息非常有限。有必要对其致病性进行进一步详细的机制研究。
