β-磷酸三钙与自体骨用于山羊模型中牙槽嵴裂修复的比较
β-TCP versus autologous bone for repair of alveolar clefts in a goat model.
作者信息
de Ruiter Ad, Meijer Gert, Dormaar Titiaan, Janssen Nard, van der Bilt Andries, Slootweg Piet, de Bruijn Joost, van Rijn Linda, Koole Ronald
出版信息
Cleft Palate Craniofac J. 2011 Nov;48(6):654-62. doi: 10.1597/09-219. Epub 2010 Aug 11.
OBJECTIVE
The aim of this study in goats was to test the hypothesis that a novel synthetic bone substitute beta tricalcium phosphate (β-TCP) can work as well as autologous bone harvested from the iliac crest for grafting and repair of alveolar clefts.
DESIGN
Ten adult Dutch milk goats (Capra hircus) were used in a split-mouth study design.
MAIN OUTCOME MEASURES
Volumetric histologic assessment of new bone formation and radiographic measurement of orthodontic movement of teeth in a formerly created alveolar cleft.
CONCLUSIONS
The synthetic bone substitute β-TCP was shown to result in bone healing similar to that of iliac crest bone. The surgical, orthodontic, and histologic results now warrant the testing of β-TCP in the human cleft situation.
目的
本研究以山羊为对象，旨在验证一种新型合成骨替代物β - 磷酸三钙（β-TCP）在牙槽嵴裂植骨修复方面的效果是否与取自髂嵴的自体骨相同这一假设。
设计
采用10只成年荷兰奶山羊（Capra hircus）进行双侧对照研究设计。
主要观察指标
对新骨形成进行体积组织学评估，并对先前形成的牙槽嵴裂中牙齿的正畸移动进行影像学测量。
结论
合成骨替代物β-TCP显示出与髂嵴骨相似的骨愈合效果。目前，手术、正畸及组织学结果表明有必要在人类腭裂病例中对β-TCP进行测试。
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