Du Fengzhou, Wu Huanhuan, Li Haidong, Cai Lei, Wang Qian, Liu Xia, Xiao Ran, Yin Ningbei, Cao Yilin
Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China.
Cleft Lip and Palate Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China.
Sci Rep. 2017 Oct 23;7(1):13773. doi: 10.1038/s41598-017-12602-1.
Alveolar cleft is the most common congenital bone defect. Autologous iliac crest bone graft (ICBG) is the most widely adopted procedure for alveolar cleft repair, but the condition is associated with door-site morbidities. For the first time, this study used bone marrow mononuclear cells (BMMNCs) combined with beta-tricalcium phosphate (β-TCP) granules to repair alveolar bone defect. The effectiveness of this technique was compared with autologous ICBG after 12 months of follow-up. The bone formation volume was quantitatively evaluated by three-dimensional computed tomography and computer aided engineering technology. BMMNCs/β-TCP granule grafting was radiographically equivalent to ICBG in alveolar cleft repair. Although considerable resorption was observed up to 6 months after surgery, no significant differences were noted in the Chelsea score and bone formation volume between groups. These finding indicate that BMMNCs/β-TCP grafting is a safe and effective approach for alveolar bone regeneration.
牙槽嵴裂是最常见的先天性骨缺损。自体髂嵴骨移植（ICBG）是牙槽嵴裂修复最广泛采用的手术方法，但该手术伴有供区并发症。本研究首次使用骨髓单个核细胞（BMMNCs）联合β-磷酸三钙（β-TCP）颗粒修复牙槽骨缺损。随访12个月后，将该技术的有效性与自体ICBG进行比较。通过三维计算机断层扫描和计算机辅助工程技术对骨形成体积进行定量评估。在牙槽嵴裂修复中，BMMNCs/β-TCP颗粒移植在影像学上与ICBG相当。尽管术后6个月观察到大量吸收，但两组之间在Chelsea评分和骨形成体积方面没有显著差异。这些发现表明，BMMNCs/β-TCP移植是牙槽骨再生的一种安全有效的方法。
