Department of Neurology, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, 2700 McGuire, Maywood, IL 60153, USA.
Neurol Clin. 2010 Nov;28(4):835-41. doi: 10.1016/j.ncl.2010.03.015. Epub 2010 May 15.
Although headache is a common ailment, its more severe manifestations such as intractable migraine, and trigeminal autonomic cephalagias including cluster headaches have a debilitating effect on patients resulting in chronic pain and severe functional impairment. Neurostimulation has been explored as a possible treatment option in selective drug-resistant primary headache disorders, in conducting clinical trials involving neurostimulation of deep brain structures, occipital nerves, and vagal nerves as treatment methods for refractory primary headache disorders, the selection of patients should be strictly based on pre-defined clinical criteria. The trials should be well designed, taking into account the potential risks and complications associated with such therapies.
尽管头痛是一种常见疾病，但它的更严重表现形式，如难治性偏头痛和三叉自主神经性头痛，包括丛集性头痛，会对患者造成衰弱影响，导致慢性疼痛和严重的功能障碍。神经刺激已被探索作为一种可能的治疗选择，用于选择性药物抵抗性原发性头痛障碍，在进行涉及深部脑结构、枕神经和迷走神经神经刺激的临床试验中，作为难治性原发性头痛障碍的治疗方法，患者的选择应严格基于预先定义的临床标准。试验应精心设计，考虑到与这些治疗相关的潜在风险和并发症。
