Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy.
Neurol Sci. 2010 Jun;31 Suppl 1:S87-92. doi: 10.1007/s10072-010-0293-6.
Drug refractory headaches constitute an important cause of social life disability; when a lack of responsiveness to conservative treatments is ascertained for these pathological conditions, surgical options are considered. Several lines of evidence exist to assert that the neuromodulation procedures available so far are safe and effective in a large amount of patients for the treatment of different types of severe primary and secondary headaches. Central (deep-brain stimulation, DBS) and peripheral [vagus nerve stimulation (VNS), occipital nerve stimulation (ONS), subcutaneous trigeminal stimulation] neuromodulation procedures are here reviewed as reported in literature along with the experience of our Institute.
药物难治性头痛是导致社会生活障碍的一个重要原因；当这些病理状况确定对保守治疗没有反应时，就会考虑手术选择。有大量证据表明，到目前为止，可用的神经调节程序在治疗不同类型的严重原发性和继发性头痛方面对大量患者来说是安全有效的。中枢（深部脑刺激，DBS）和外周[迷走神经刺激（VNS）、枕神经刺激（ONS）、皮下三叉神经刺激]神经调节程序在这里与我们研究所的经验一起，根据文献进行了综述。
