Dipartimento di Matematica e Applicazioni, Università di Milano Bicocca, via Cozzi, 53; I-20125 Milano, Italy.
J Theor Biol. 2010 Dec 21;267(4):614-25. doi: 10.1016/j.jtbi.2010.08.017. Epub 2010 Sep 8.
We consider models of Ran-driven nuclear transport of molecules such as proteins in living cells. The mathematical model presented is the first to take into account for the active transport of molecules along the cytoplasmic microtubules. All parameters entering the models are thoroughly discussed. The model is tested by numerical simulations based on discontinuous Galerkin finite element methods. The numerical experiments are compared to the behavior observed experimentally.
我们研究了 Ran 驱动的分子（如蛋白质）在活细胞中的核运输模型。所提出的数学模型首次考虑了分子沿着细胞质微管的主动运输。模型中涉及的所有参数都进行了深入讨论。该模型通过基于间断 Galerkin 有限元方法的数值模拟进行了测试。数值实验与实验观察到的行为进行了比较。
