School of Pharmacy, Pharm. Tech., University of Eastern Finland, Kuopio Campus, P.O.B. 1627, FI-70211 Kuopio, Finland.
Int J Pharm. 2010 Nov 15;400(1-2):104-13. doi: 10.1016/j.ijpharm.2010.08.038. Epub 2010 Sep 9.
An ultrasound measurement system for tablet defect detection is introduced. The measurement system was implemented in an eccentric single station tabletting apparatus, where ultrasound transducers were placed inside the upper and lower punches. These instrumented punches were then used to measure the speed of sound and ultrasound attenuation values in both intact and defective tablets made from dibasic calcium phosphate, microcrystalline cellulose and lactose monohydrate. Ultrasound attenuation was found to be a very sensitive method to discriminate defective tablets from intact ones. In addition, it was found that the determined ultrasound attenuation was different between all three materials used in this study, which indicates that different materials could be distinguished from one another by this detection method.
介绍了一种用于片剂缺陷检测的超声测量系统。该测量系统在偏心单工位压片机中实现，其中超声换能器置于上下冲头内部。然后，使用这些仪器化冲头测量由磷酸氢钙、微晶纤维素和一水乳糖制成的完整和有缺陷片剂中的声速和超声衰减值。研究发现，超声衰减是一种非常敏感的方法，可以区分有缺陷的片剂和完整的片剂。此外，还发现本研究中使用的所有三种材料的超声衰减值存在差异，这表明可以通过这种检测方法将不同的材料彼此区分开来。
