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[片剂辅料的脱水损失对能量-距离图及片剂特性的影响]

[The effect of dehydration loss of tablet excipients on the energy- distance diagram and on tablet characteristics].

作者信息

Wenzel U, Kala H

出版信息

Pharmazie. 1984 Dec;39(12):819-21.

PMID:6531390
Abstract

Four tabletting agents of the micro-crystalline cellulose type (Heweten 10, Heweten 12, Heweten 40 and Avicel PH 101) as well as a potato starch lactose granulate had been tabletted on an instrumented slow-motion eccentric press (1 r. p. m.) following storage at different relative humidities. The data resulting from force-punch displacement measurements had been related to the radial steadiness to breakage and the dehydration loss of the relevant agent.

摘要

四种微晶纤维素类型的压片剂(Heweten 10、Heweten 12、Heweten 40和Avicel PH 101)以及一种马铃薯淀粉乳糖颗粒剂,在不同相对湿度下储存后,在一台带仪器的慢动作偏心压力机(每分钟1转)上进行压片。由力-冲头位移测量得出的数据与相关药剂的径向抗破损稳定性和脱水损失有关。

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