下丘脑 2-花生四烯酸甘油增加通过激活大麻素 1 受体诱导高脂肪饮食偏好。
Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors.
机构信息
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
出版信息
Behav Brain Res. 2011 Jan 1;216(1):477-80. doi: 10.1016/j.bbr.2010.08.042. Epub 2010 Sep 9.
The aim of the present study is to examine the relationship between preference for HFD and 2-arachidonoylglycerol (2-AG), endogenous cannabinoid. The 3-day HFD intake induced preference for HFD, which was suppressed by CB1 antagonist, O-2050. Moreover, hypothalamic 2-AG was increased after 3-day HFD intake. Our results show that preference for HFD is induced by activation of CB1 receptors via an increment of 2-AG in hypothalamus.
本研究旨在探讨高脂饲料（HFD）偏好与内源性大麻素 2-花生四烯酸甘油（2-AG）之间的关系。3 天的 HFD 摄入诱导了对 HFD 的偏好，这种偏好被 CB1 拮抗剂 O-2050 抑制。此外，3 天的 HFD 摄入后下丘脑的 2-AG 增加。我们的结果表明，HFD 偏好是通过激活下丘脑的 CB1 受体，增加 2-AG 而诱导的。
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