Joint Diabetes, Endocrinology & Metabolism Program, Louisiana State University System, Louisiana State University Health Science Center-New Orleans, New Orleans, USA.
Pennington Biomedical Research Center, Baton Rouge, USA.
Horm Metab Res. 2013 Dec;45(13):967-74. doi: 10.1055/s-0033-1353181. Epub 2013 Aug 26.
QRFP, a member of the RFamide-related peptide family, is a strongly conserved hypothalamic neuropeptide that has been characterized in various species. Prepro-QRFP mRNA expression is localized to select regions of the hypothalamus, which are involved in the regulation of feeding behavior. The localization of the peptide precursor has led to the assessment of QRFP on feeding behaviors and the orexigenic effects of QRFP have been detected in mice, rats, and birds. QRFP acts in a macronutrient specific manner in satiated rats to increase the intake of a high fat diet, but not the intake of a low fat diet, and increases the intake of chow in food-restricted rats. Studies suggest that QRFP's effects on food intake are mediated by the adiposity signal, leptin, and hypothalamic neuropeptides. Additionally, QRFP regulates the expression and release of hypothalamic Neuropeptide Y and proopiomelanocortin/α-Melanocyte-Stimulating Hormone. QRFP binds to receptors throughout the brain, including regions associated with food intake and reward. Taken together, these data suggest that QRFP is a mediator of motivated behaviors, particularly the drive to ingest high fat food. The present review discusses the role of QRFP in the regulation of feeding behavior, with emphasis on the intake of dietary fat.
QRFP 是 RFamide 相关肽家族的成员，是一种在各种物种中都具有强烈保守性的下丘脑神经肽，其特征已被确定。Prepro-QRFP mRNA 的表达定位于下丘脑的特定区域，这些区域参与进食行为的调节。肽前体的定位导致了对 QRFP 对进食行为的评估，并且已经在小鼠、大鼠和鸟类中检测到 QRFP 的致食欲作用。QRFP 在饱腹大鼠中以特定于宏量营养素的方式起作用，增加高脂肪饮食的摄入，但不增加低脂肪饮食的摄入，并增加限制食物的大鼠的食量。研究表明，QRFP 对食物摄入的影响是通过肥胖信号、瘦素和下丘脑神经肽介导的。此外，QRFP 调节下丘脑神经肽 Y 和 proopiomelanocortin/α-Melanocyte-Stimulating Hormone 的表达和释放。QRFP 与大脑中的受体结合，包括与食物摄入和奖励相关的区域。总之，这些数据表明 QRFP 是动机行为的介导物，特别是摄入高脂肪食物的驱动力。本综述讨论了 QRFP 在调节进食行为中的作用，重点是饮食脂肪的摄入。
