便携式微接触印刷细胞培养装置。

Portable microcontact printing device for cell culture.

机构信息

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

出版信息

Biomaterials. 2010 Dec;31(34):8974-9. doi: 10.1016/j.biomaterials.2010.08.019.

DOI:10.1016/j.biomaterials.2010.08.019

PMID:20817249

Abstract

In this work, we developed a portable device to perform microcontact printing in a safety cabinet for cell culture. The device was designed to be small and non-bulky, easy to sterilize, while not requiring the use of electricity, and which requires very little manual handling. Moreover, the portable microcontact printer is reproducibly fabricated with a rapid prototyping system, and allows for the easy micropatterning of biomolecules with a resolution ranging from 20 to 500 μm. This opens new horizons in the direct and simple micropatterning of culture dishes and the mimicking and biofabrication of complex architectures of tissues.

摘要

在这项工作中，我们开发了一种用于细胞培养的安全柜中的微接触印刷的便携式设备。该设备设计为小巧、不笨重，易于消毒，无需用电，并且几乎不需要手动操作。此外，便携式微接触打印机可通过快速原型制作系统重复制造，并且允许使用分辨率为 20 至 500μm 的生物分子进行轻松的微图案化。这为直接和简单的培养皿微图案化以及组织的复杂结构的模拟和生物制造开辟了新的前景。