Department of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster, D-48149 Münster, Germany.
Curr Opin Cell Biol. 2010 Oct;22(5):617-25. doi: 10.1016/j.ceb.2010.08.010.
The vertebrate body contains an extensive blood vessel network that forms, with a few exceptions, by endothelial sprouting from the existing vasculature. This process, termed angiogenesis, involves complex and highly dynamic interactions between endothelial cells and their environment. Pro-angiogenic signals, such as VEGF, promote endothelial motility, filopodia extension and proliferation, and, together with Notch signaling, controls whether specific endothelial cells become lead tip cells or trailing stalk cells. Sprouts then convert into endothelial tubules and form connections with other vessels, which requires the local suppression of motility and the formation of new cell-cell junctions. We here review the dynamics of angiogenesis in the context of key molecules and pathways controlling tip cell selection, sprouting and the formation of new vessels.
脊椎动物体内含有广泛的血管网络，除了少数例外，这些血管都是通过内皮细胞从现有血管中发芽形成的。这个过程被称为血管生成，涉及内皮细胞与其环境之间复杂而高度动态的相互作用。促血管生成信号，如 VEGF，促进内皮细胞的运动、丝状伪足的延伸和增殖，并且与 Notch 信号一起，控制特定的内皮细胞成为引导尖端细胞还是尾随的茎细胞。然后，芽体转化为内皮小管，并与其他血管形成连接，这需要局部抑制运动和形成新的细胞-细胞连接。我们在这里回顾了控制尖端细胞选择、发芽和新血管形成的关键分子和途径背景下的血管生成动力学。
