应用背向散射分析的定量超声在杜氏肌营养不良症和贝克型肌营养不良症中的应用。
Quantitative ultrasound using backscatter analysis in Duchenne and Becker muscular dystrophy.
机构信息
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Neuromuscul Disord. 2010 Dec;20(12):805-9. doi: 10.1016/j.nmd.2010.06.019.
Abstract
Evaluation of ultrasound images of muscle with calibrated muscle backscatter (cMB) provides reproducible quantitative measurements of muscle pathology. Increased cMB is associated with greater muscle pathology. We used cMB to evaluate the severity of muscle pathology in 55 patients with Duchenne and Becker Muscular Dystrophy (D/BMD) compared to 77 controls. cMB was also compared to measurements of strength and function. cMB in DMD and BMD increased linearly with age and was higher than in controls when groups are compared. cMB increased twice as fast with age in DMD than in BMD. In DMD, cMB was higher with reduced function and strength. Ultrasound measurement of muscle pathology using cMB is a sensitive and objective quantitative technique for determining the severity of muscle pathology in dystrophinopathies. Longitudinal studies are required to determine the sensitivity of this measure to changes in pathology over time.
摘要
采用校准肌肉背散射（cMB）的超声图像评估可提供肌肉病理学的重复性定量测量。cMB 增加与更大的肌肉病理学相关。我们使用 cMB 评估了 55 名杜氏和贝克型肌营养不良症（D/BMD）患者与 77 名对照者的肌肉病理学严重程度。cMB 也与力量和功能的测量进行了比较。DMD 和 BMD 的 cMB 随年龄呈线性增加，与对照组相比更高。DMD 中 cMB 的年龄增长速度比 BMD 快两倍。在 DMD 中，cMB 与功能和力量降低有关。使用 cMB 的肌肉病理学超声测量是一种敏感和客观的定量技术，用于确定肌营养不良症中肌肉病理学的严重程度。需要进行纵向研究以确定该指标对随时间变化的病理学变化的敏感性。
相似文献
1
Quantitative ultrasound using backscatter analysis in Duchenne and Becker muscular dystrophy.
Neuromuscul Disord. 2010 Dec;20(12):805-9. doi: 10.1016/j.nmd.2010.06.019.
2
Muscle ultrasound quantifies disease progression over time in infants and young boys with duchenne muscular dystrophy.
Muscle Nerve. 2015 Sep;52(3):334-8. doi: 10.1002/mus.24609.
3
Quantitative muscle ultrasound is a promising longitudinal follow-up tool in Duchenne muscular dystrophy.
Neuromuscul Disord. 2012 Apr;22(4):306-17. doi: 10.1016/j.nmd.2011.10.020. Epub 2011 Nov 30.
4
Intramuscular blood flow in Duchenne and Becker Muscular Dystrophy: Quantitative power Doppler sonography relates to disease severity.
Clin Neurophysiol. 2020 Jan;131(1):1-5. doi: 10.1016/j.clinph.2019.09.023. Epub 2019 Nov 4.
5
Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver.
Ultrasound Med Biol. 2007 Aug;33(8):1236-43. doi: 10.1016/j.ultrasmedbio.2007.02.007. Epub 2007 Apr 30.
6
Cross-sectional evaluation of electrical impedance myography and quantitative ultrasound for the assessment of Duchenne muscular dystrophy in a clinical trial setting.
Pediatr Neurol. 2014 Jul;51(1):88-92. doi: 10.1016/j.pediatrneurol.2014.02.015. Epub 2014 Feb 28.
7
Valley sign in Becker muscular dystrophy and outliers of Duchenne and Becker muscular dystrophy.
Neurol India. 2004 Jun;52(2):203-5.
8
Muscular dystrophy patients show low exercise-induced blood flow in muscles with normal strength.
Ann Clin Transl Neurol. 2024 Nov;11(11):2866-2876. doi: 10.1002/acn3.52194. Epub 2024 Sep 9.
9
Abnormal lipid metabolism in skeletal muscle tissue of patients with muscular dystrophy: In vitro, high-resolution NMR spectroscopy based observation in early phase of the disease.
Magn Reson Imaging. 2017 May;38:163-173. doi: 10.1016/j.mri.2017.01.001. Epub 2017 Jan 7.
10
Quantitative muscle ultrasound in Duchenne muscular dystrophy: a comparison of techniques.
Muscle Nerve. 2015 Feb;51(2):207-13. doi: 10.1002/mus.24296. Epub 2014 Dec 23.
引用本文的文献
1
3D finite element models reveal regional fatty infiltration modulates tibialis anterior force generating capacity in FSHD.
PLoS One. 2025 Jul 18;20(7):e0319881. doi: 10.1371/journal.pone.0319881. eCollection 2025.
2
Quantitative Muscle Ultrasound: A Non-Invasive Biomarker for Monitoring Duchenne Muscular Dystrophy.
Muscle Nerve. 2025 Oct;72(4):606-615. doi: 10.1002/mus.28469. Epub 2025 Jul 16.
3
Radiomics with Ultrasound Radiofrequency Data for Improving Evaluation of Duchenne Muscular Dystrophy.
J Imaging Inform Med. 2025 Mar 14. doi: 10.1007/s10278-025-01450-5.
4
Ultrasound-based assessment of the expression of inflammatory markers in the rectus femoris muscle of rats.
Exp Biol Med (Maywood). 2024 Feb 29;249:10064. doi: 10.3389/ebm.2024.10064. eCollection 2024.
5
Deep Learning of Ultrasound Imaging for Evaluating Ambulatory Function of Individuals with Duchenne Muscular Dystrophy.
Diagnostics (Basel). 2021 May 27;11(6):963. doi: 10.3390/diagnostics11060963.
6
Three-dimensional quantitative muscle ultrasound in a healthy population.
Muscle Nerve. 2021 Aug;64(2):199-205. doi: 10.1002/mus.27330. Epub 2021 Jun 8.
7
Clinical Evaluation of Duchenne Muscular Dystrophy Severity Using Ultrasound Small-Window Entropy Imaging.
Entropy (Basel). 2020 Jun 28;22(7):715. doi: 10.3390/e22070715.
8
Intramuscular blood flow in Duchenne and Becker Muscular Dystrophy: Quantitative power Doppler sonography relates to disease severity.
Clin Neurophysiol. 2020 Jan;131(1):1-5. doi: 10.1016/j.clinph.2019.09.023. Epub 2019 Nov 4.
9
Quantitative ultrasound of muscle can detect corticosteroid effects.
Clin Neurophysiol. 2019 Aug;130(8):1460-1464. doi: 10.1016/j.clinph.2019.04.709. Epub 2019 May 10.
10
Influence of Ultrasound System and Gain on Grayscale Median Values.
J Ultrasound Med. 2019 Feb;38(2):307-319. doi: 10.1002/jum.14690. Epub 2018 Jul 19.
本文引用的文献
1
Skeletal muscle ultrasound: correlation between fibrous tissue and echo intensity.
Ultrasound Med Biol. 2009 Mar;35(3):443-6. doi: 10.1016/j.ultrasmedbio.2008.09.016. Epub 2008 Dec 10.
2
Calibrated quantitative ultrasound imaging of skeletal muscle using backscatter analysis.
Muscle Nerve. 2008 Jul;38(1):893-8. doi: 10.1002/mus.21052.
3
Three-point technique of fat quantification of muscle tissue as a marker of disease progression in Duchenne muscular dystrophy: preliminary study.
AJR Am J Roentgenol. 2008 Jan;190(1):W8-12. doi: 10.2214/AJR.07.2732.
4
Sensitive ultrasonic delineation of steroid treatment in living dystrophic mice with energy-based and entropy-based radio frequency signal processing.
IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Nov;54(11):2291-9. doi: 10.1109/tuffc.2007.533.
5
Measurements of the cyclic variation of myocardial backscatter from two-dimensional echocardiographic images as an approach for characterizing diabetic cardiomyopathy.
J Cardiometab Syndr. 2006 Spring;1(2):149-52. doi: 10.1111/j.1559-4564.2006.05493.x.
6
Quantitative skeletal muscle ultrasound: diagnostic value in childhood neuromuscular disease.
Neuromuscul Disord. 2007 Jul;17(7):509-16. doi: 10.1016/j.nmd.2007.03.008. Epub 2007 May 29.
7
Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with duchenne muscular dystrophy using an entropy-based signal receiver.
Ultrasound Med Biol. 2007 Aug;33(8):1236-43. doi: 10.1016/j.ultrasmedbio.2007.02.007. Epub 2007 Apr 30.
8
Reliable surrogate outcome measures in multicenter clinical trials of Duchenne muscular dystrophy.
Muscle Nerve. 2007 Jan;35(1):36-42. doi: 10.1002/mus.20654.
9
Skeletal muscle ultrasonography: Visual versus quantitative evaluation.
Ultrasound Med Biol. 2006 Sep;32(9):1315-21. doi: 10.1016/j.ultrasmedbio.2006.05.028.
10
Compositional analysis of muscle in boys with Duchenne muscular dystrophy using MR imaging.
Skeletal Radiol. 2005 Mar;34(3):140-8. doi: 10.1007/s00256-004-0825-3. Epub 2004 Oct 22.
Zotero 插件