Pillen S, Verrips A, van Alfen N, Arts I M P, Sie L T L, Zwarts M J
Department of Clinical Neurophysiology, Institute of Neurology, Neuromuscular Centre Nijmegen, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Neuromuscul Disord. 2007 Jul;17(7):509-16. doi: 10.1016/j.nmd.2007.03.008. Epub 2007 May 29.
In this study we investigated the diagnostic value of quantitative skeletal muscle ultrasonography in 150 consecutively referred children with symptoms suspect for a neuromuscular disorder. Muscle thickness and quantitatively determined echo intensity of four muscles and the distribution of these variables within the body were examined.
Patients with and without a neuromuscular disorder could be discriminated with a positive predictive value of 91% and a negative predictive value of 86%. Patients with a neurogenic disorder could be distinguished from myopathies and non-neuromuscular disorders with a positive predictive value of 86% and a negative predictive of 84%, using the pattern of distribution of pathology within the body.
Skeletal muscle ultrasound is a good, practical and non-invasive aid in the diagnosis of neuromuscular disorders in children, that is able to discriminate between children with and without a neuromuscular disorder and between neurogenic disorders and myopathies with high predictive values.
在本研究中，我们调查了定量骨骼肌超声检查对150例连续转诊的、有疑似神经肌肉疾病症状儿童的诊断价值。检查了四块肌肉的厚度、定量测定的回声强度以及这些变量在体内的分布情况。
患有和未患有神经肌肉疾病的患者能够被区分开，阳性预测值为91%，阴性预测值为86%。利用病理在体内的分布模式，患有神经源性疾病的患者能够与肌病和非神经肌肉疾病区分开，阳性预测值为86%，阴性预测值为84%。
骨骼肌超声是诊断儿童神经肌肉疾病的一种良好、实用且非侵入性的辅助手段，能够以较高的预测值区分患有和未患有神经肌肉疾病的儿童，以及神经源性疾病和肌病。
