Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada, B3H1X5.
Trends Endocrinol Metab. 2010 Nov;21(11):660-7. doi: 10.1016/j.tem.2010.08.001.
Chemerin is a secreted protein with a complex but well-established role in immune function. Parallel lines of investigation also support the notion that chemerin is a novel adipokine that regulates adipocyte development and metabolic function as well as glucose metabolism in liver and skeletal muscle tissues. A growing body of human experimental data indicates that serum chemerin levels are elevated in patients with obesity and that they exhibit a positive correlation with various aspects of the metabolic syndrome. Thus, the dual role of chemerin in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease.
趋化素是一种分泌蛋白，在免疫功能中具有复杂而明确的作用。平行的研究也支持这样一种观点，即趋化素是一种新型脂肪因子，可调节脂肪细胞的发育和代谢功能，以及肝脏和骨骼肌组织中的葡萄糖代谢。越来越多的人体实验数据表明，肥胖症患者的血清趋化素水平升高，并且它们与代谢综合征的各个方面呈正相关。因此，趋化素在炎症和代谢中的双重作用可能为慢性炎症与肥胖以及肥胖相关疾病（如 2 型糖尿病和心血管疾病）之间提供了联系。
