Department of Psychiatry, ULSS20, Verona, Italy.
Psychiatry Res. 2010 Oct 30;184(1):23-8. doi: 10.1016/j.pscychresns.2010.05.012.
Volumetric changes in mood-relevant distributed limbic/paralimbic structures have been reported in the recent literature on the course of mood disorders. Patients with unipolar and bipolar disorders have been found to have smaller hippocampal and anterior cingulate volumes. We examined hippocampal, amygdalar and anterior cingulate cortex (ACC) volumes in female patients with recurrent familial pure depressive disorder (rFPDD). We used semi-automated software for magnetic resonance imaging (MRI) to measure the volumes of the hippocampus, amygdala, ACC and subgenual prefrontal cortex (SGPFC) in 15 female patients with familial recurrent major depression (MD) and 15 healthy female subjects. Analysis of covariance, with whole brain volume as covariate, was used to compare volumetric measurements in the two groups. Volumes of the right hippocampal body and tail were significantly smaller in female patients with familial depressive disorder than in healthy subjects. Our data provide evidence of structural lateralized hippocampal body and tail abnormalities in women with familial history and recurrent episodes of depression. Although global reduction of hippocampal volume has been widely reported, data on lateralized regional reductions in familial recurrent depression had not been previously reported. Reduced volume of the right posterior hippocampus could be a structural endophenotype for recurrent depressive disorders in women.
在心境障碍病程的近期文献中，报告了与情绪相关的分布式边缘/边缘下结构的容积变化。单相和双相障碍患者的海马体和前扣带回体积较小。我们检查了复发性家族性单纯性抑郁障碍（rFPDD）女性患者的海马体、杏仁核和前扣带回皮质（ACC）体积。我们使用磁共振成像（MRI）半自动软件测量了 15 名家族性复发性重度抑郁症（MD）女性患者和 15 名健康女性受试者的海马体、杏仁核、ACC 和前扣带回下额皮质（SGPFC）体积。使用协方差分析，以全脑体积为协变量，比较两组的容积测量值。家族性抑郁障碍女性患者的右侧海马体和尾部体积明显小于健康受试者。我们的数据提供了家族史和反复发作抑郁的女性存在结构侧化海马体和尾部异常的证据。尽管广泛报道了海马体体积的整体减少，但以前没有报道过家族性复发性抑郁中侧化区域性减少的数据。右侧后海马体体积减少可能是女性复发性抑郁障碍的结构内表型。
