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PLA2R autoantibodies and recurrent membranous nephropathy after transplantation.

作者信息

Stahl Rolf, Hoxha Elion, Fechner Kai

出版信息

N Engl J Med. 2010 Jul 29;363(5):496-8. doi: 10.1056/NEJMc1003066.

DOI:10.1056/NEJMc1003066
PMID:20818871
Abstract
摘要

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PLA2R autoantibodies and recurrent membranous nephropathy after transplantation.磷脂酶A2受体自身抗体与移植后复发性膜性肾病
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Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy.肾小球中 M 型磷脂酶 A2 受体的表达增强与原发性膜性肾病患者血清受体抗体相关。
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PM2.5-induced oxidative stress upregulates PLA2R expression in the lung and is involved in the pathogenesis of membranous nephropathy through extracellular vesicles.细颗粒物2.5（PM2.5）诱导的氧化应激上调肺部磷脂酶A2受体（PLA2R）的表达，并通过细胞外囊泡参与膜性肾病的发病机制。
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