Kerkhofs M, Rielaert C, de Maertelaer V, Linkowski P, Czarka M, Mendlewicz J
Sleep Laboratory Department of Psychiatry, Erasme Hospital, Bruxelles, Belgium.
Int Clin Psychopharmacol. 1990 Oct;5(4):253-60.
Fluoxetine (60 mg), a selective inhibitor of the reuptake of 5-HT, was compared in a double-blind trial to amitriptyline (150 mg) in a sample of 34 patients fitting the Research Diagnostic Criteria for a major depressive disorder. Patients were studied after a drug washout period of 10 days and an active treatment period of 42 days. Sleep polygraphic recordings were performed before and at the end of the study. As indicated by the significant decrease in the Hamilton Depression scale and the Montgomery Asberg Depression scale, fluoxetine showed similar antidepressant effects to amitriptyline with significantly fewer adverse effects. Fluoxetine and amitriptyline decreased the amount of REM sleep, a well known effect of classical antidepressants. Fluoxetine showed some specific effects on sleep continuity (potentially dose related) as indicated by the significant increase in the number of awakenings and in stage shifts, without interfering with the therapeutic response.
在一项双盲试验中，对34名符合重性抑郁障碍研究诊断标准的患者，比较了5-羟色胺再摄取选择性抑制剂氟西汀（60毫克）与阿米替林（150毫克）的疗效。患者在经过10天的药物洗脱期和42天的积极治疗期后接受研究。在研究开始前和结束时进行睡眠多导记录。正如汉密尔顿抑郁量表和蒙哥马利-阿斯伯格抑郁量表显著下降所示，氟西汀显示出与阿米替林相似的抗抑郁效果，且不良反应明显较少。氟西汀和阿米替林减少了快速眼动睡眠量，这是经典抗抑郁药的一个众所周知的效果。氟西汀对睡眠连续性有一些特定影响（可能与剂量有关），表现为觉醒次数和睡眠阶段转换次数显著增加，但不影响治疗反应。
