Stony Brook University Medical Center, Department of Neurology, Stony Brook, NY 11794-8121, USA.
Expert Rev Neurother. 2010 Sep;10(9):1437-47. doi: 10.1586/ern.10.99.
Fatigue is an extremely prevalent issue for multiple sclerosis (MS) patients. Fatigue can affect quality of life, depression, anxiety, motor function and sleep patterns. There are a number of available rating scales designed to detect and assess fatigue. However, the pathophysiology of fatigue is still not completely understood and the treatment of this symptom remains difficult. A number of clinical trials for fatigue in MS have shown some benefit with different interventions, including medication, physical activity and cognitive-behavioral therapy. Nonetheless, further research and the development of more targeted therapies are needed to improve the management of fatigue.
疲劳是多发性硬化症（MS）患者极为常见的问题。疲劳会影响生活质量、抑郁、焦虑、运动功能和睡眠模式。有许多现有的评分量表旨在检测和评估疲劳。然而，疲劳的病理生理学仍不完全清楚，这种症状的治疗仍然很困难。一些多发性硬化症疲劳的临床试验显示，不同干预措施（包括药物、身体活动和认知行为疗法）都有一定的益处。尽管如此，仍需要进一步的研究和更有针对性的治疗方法的开发，以改善疲劳的管理。
