Division of Clinical Neurology, University of Nottingham, United Kingdom.
J Neurol Sci. 2012 Dec 15;323(1-2):9-15. doi: 10.1016/j.jns.2012.08.007. Epub 2012 Aug 27.
Fatigue is the most common and debilitating symptom in multiple sclerosis (MS) and is believed to be distinctly different from fatigue seen in other chronic conditions. It can affect a patient's mood, sleep and have a detrimental effect on their quality of life. In the recent years much literature has emerged in an attempt to elucidate the potential causes and treatment of this common symptom. This review article aims to examine the most recent theories on the pathophysiology of fatigue in MS as well as its association with sleep and depression. We describe the pharmacological and non-pharmacological approaches to its treatment and propose a multidisciplinary, patient enabled and individualised manner to the management of fatigue in MS.
疲劳是多发性硬化症（MS）中最常见和最具致残性的症状，据信它与其他慢性疾病中出现的疲劳明显不同。它会影响患者的情绪、睡眠，并对其生活质量产生不利影响。近年来，出现了大量文献试图阐明这种常见症状的潜在原因和治疗方法。本文旨在探讨 MS 疲劳的病理生理学的最新理论及其与睡眠和抑郁的关系。我们描述了其治疗的药物和非药物方法，并提出了一种多学科、以患者为中心和个体化的方式来管理 MS 中的疲劳。
