Zhang Y, Tong X
Department of Obstetrics and Gynaecology, Tongji Hospital of Tongji University, Shanghai, China.
J Int Med Res. 2010 May-Jun;38(3):1042-8. doi: 10.1177/147323001003800331.
This study was designed to investigate the expression of four actin-binding proteins, alpha-actinin-4, cofilin 1, fascin and elongation factor 1-alpha 2 (eEF1A2), in samples of breast cancer from 112 patients with different stages of breast cancer (stages T0 - T1, T2 and T3) compared with normal control tissues (n = 33). Levels of eEF1A2 and alpha-actinin-4 mRNA appeared to be unrelated to tumour size, except for a significant down-regulation of alpha-actinin-4 mRNA in T3 cases. Significant up-regulation of cofilin 1 mRNA was associated with stages T0 - T1 and T2; up-regulation seen at stage T3 was not significant compared with control tissue. Fascin mRNA levels were significantly reduced at all three tumour stages (T0 - T1, T2 and T3) compared with control tissue. In conclusion, some components of the actin cytoskeletal system might hold significant potential as targets in future cancer therapies.
本研究旨在调查112例处于不同乳腺癌阶段（T0 - T1期、T2期和T3期）的患者的乳腺癌样本中四种肌动蛋白结合蛋白，即α - 辅肌动蛋白 - 4、丝切蛋白1、丝束蛋白和延伸因子1 - α 2（eEF1A2）的表达情况，并与正常对照组织（n = 33）进行比较。eEF1A2和α - 辅肌动蛋白 - 4 mRNA水平似乎与肿瘤大小无关，不过在T3期病例中α - 辅肌动蛋白 - 4 mRNA有显著下调。丝切蛋白1 mRNA的显著上调与T0 - T1期和T2期相关；与对照组织相比，T3期的上调并不显著。与对照组织相比，在所有三个肿瘤阶段（T0 - T1期、T2期和T3期）丝束蛋白mRNA水平均显著降低。总之，肌动蛋白细胞骨架系统的某些成分可能在未来癌症治疗中具有作为靶点的巨大潜力。
