哮喘合并慢性阻塞性肺疾病大鼠的气道炎症特征及下丘脑-垂体-肾上腺轴功能。
Inflammatory airway features and hypothalamic-pituitary-adrenal axis function in asthmatic rats combined with chronic obstructive pulmonary disease.
机构信息
Lab of Integrative Medicine for Lung, Inflammation and Cancers, Huashan Hospital, Fudan University, Shanghai 200040, China.
出版信息
Chin Med J (Engl). 2010 Jul;123(13):1720-6.
BACKGROUND
Bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) are both inflammatory airway diseases with different characteristics. However, there are many patients who suffer from both BA and COPD. This study was to evaluate changes of inflammatory airway features and hypothalamic-pituitary-adrenal (HPA) axis function in asthmatic rats combined with COPD.
METHODS
Brown Norway (BN) rats were used to model the inflammatory airway diseases of BA, COPD and COPD + BA. These three models were compared and evaluated with respect to clinical symptoms, pulmonary histopathology, airway hyperresponsiveness (AHR), inflammatory cytokines and HPA axis function.
RESULTS
The inflammatory airway features and HPA axis function in rats in the COPD + BA model group were greatly influenced. Rats in this model group showed features of the inflammatory diseases BA and COPD. The expression of inflammatory cytokines in this model group might be up or downregulated when both disease processes are present. The levels of corticotrophin releasing hormone mRNA and corticosterone in this model group were both significantly decreased than those in the control group (P < 0.05).
CONCLUSIONS
BN rat can be used as an animal model of COPD + BA. By evaluating this animal model we found that the features of inflammation in rats in this model group seem to be exaggerated. The HPA axis functions in rats in this model group have been disturbed or impaired, which is prominent at the hypothalamic level.
背景
支气管哮喘（BA）和慢性阻塞性肺疾病（COPD）都是具有不同特征的炎症性气道疾病。然而，有许多患者同时患有 BA 和 COPD。本研究旨在评估哮喘合并 COPD 大鼠炎症气道特征和下丘脑-垂体-肾上腺（HPA）轴功能的变化。
方法
采用棕色挪威（BN）大鼠建立 BA、COPD 和 COPD+BA 炎症气道疾病模型，比较和评价三组模型的临床症状、肺组织病理学、气道高反应性（AHR）、炎症细胞因子和 HPA 轴功能。
结果
COPD+BA 模型组大鼠的炎症气道特征和 HPA 轴功能受到较大影响。该模型组大鼠表现出 BA 和 COPD 炎症性疾病的特征。当两种疾病过程同时存在时，模型组大鼠的炎症细胞因子表达可能会上调或下调。模型组大鼠促肾上腺皮质激素释放激素 mRNA 和皮质酮水平均明显低于对照组（P<0.05）。
结论
BN 大鼠可作为 COPD+BA 的动物模型。通过对该动物模型的评估，我们发现模型组大鼠的炎症特征似乎被夸大了。模型组大鼠的 HPA 轴功能受到干扰或损害，以下丘脑水平更为明显。
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