Caulfield Jasmine I, Cavigelli Sonia A
Pennsylvania State University, Huck Institute for Life Sciences, 101 Life Sciences Building, University Park, PA 16802, USA; Pennsylvania State University, Department of Biobehavioral Health, 219 Biobehavioral Health Building, University Park, PA 16802, USA; Pennsylvania State University, Center for Brain, Behavior, and Cognition, University Park, PA 16802, USA.
Front Neuroendocrinol. 2020 Jan;56:100803. doi: 10.1016/j.yfrne.2019.100803. Epub 2019 Nov 4.
Glucocorticoid (GC) signaling varies among individuals, and this variation may relate to individual differences in health outcomes. To determine if and which aspects of signaling (basal, circadian, integrative, or reactivity) are associated with specific health outcomes, we reviewed recent studies that relate GCs to health outcomes. We identified papers through PubMed and reviewed 100 original research articles related to mental health, cardiovascular health, cancer, diabetes, obesity, pulmonary health, sleep, and fitness. Many studies reported elevated GC secretion associated with worse health, but this was only particularly true for integrative GC measures. On the other hand, accentuated cortisol awakening response and a steeper circadian rhythm were both associated with positive health outcomes. Overall, relationships between GC secretion and health outcomes were relatively weak. This systematic review of relationships between GC metrics and health outcomes highlights the importance of careful consideration when selecting methods to measure GC regulation in health research.
糖皮质激素（GC）信号在个体间存在差异，这种差异可能与健康结果的个体差异有关。为了确定信号传导的哪些方面（基础、昼夜节律、综合或反应性）与特定健康结果相关，我们回顾了最近将糖皮质激素与健康结果相关联的研究。我们通过PubMed识别论文，并审查了100篇与心理健康、心血管健康、癌症、糖尿病、肥胖、肺部健康、睡眠和健康状况相关的原创研究文章。许多研究报告称，GC分泌升高与较差的健康状况相关，但这仅在综合GC测量中尤为明显。另一方面，明显的皮质醇觉醒反应和较陡的昼夜节律均与积极的健康结果相关。总体而言，GC分泌与健康结果之间的关系相对较弱。对GC指标与健康结果之间关系的这一系统综述强调了在健康研究中选择测量GC调节的方法时进行仔细考虑的重要性。
