Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
J Trop Pediatr. 2011 Jun;57(3):185-91. doi: 10.1093/tropej/fmq078. Epub 2010 Sep 5.
Melioidosis, an infection caused by Burkholderia pseudomallei, can present as severe septicemia or localized infection. Data on optimum antibiotic treatment regimen for localized melioidosis in children is limited. This is a report on localized melioidosis in children, regarding clinical presentation, treatment and the long-term outcomes. We reviewed 37 cases of localized melioidosis in children treated between 1994 and 2006 and followed up them prospectively until 1 October 2007. The two most common presentations were skin/soft tissue infections and suppurative parotitis. Oral eradication antibiotics after initial parenteral therapy included trimetroprim-sulfamethoxazole (10 patients) and trimetroprim-sulfamethoxazole in combination with doxycycline (four patients). Patients who did not get any parenteral antibiotics for B. pseudomallei were treated with oral trimetroprim-sulfamethoxazole (10 patients) and trimetroprim-sulfamethoxazole in combination with doxycycline (one patient). No adverse effects were reported. We were able to follow-up 32 patients, all recovered except one patient reported a history of possible relapse.
类鼻疽是由类鼻疽伯克霍尔德菌引起的感染，可表现为严重败血症或局部感染。儿童局限性类鼻疽的最佳抗生素治疗方案的数据有限。本研究报告了儿童局限性类鼻疽的临床特征、治疗和长期预后。我们回顾了 1994 年至 2006 年间治疗的 37 例儿童局限性类鼻疽病例，并前瞻性随访至 2007 年 10 月 1 日。最常见的两种表现是皮肤/软组织感染和化脓性腮腺炎。初始静脉治疗后口服清除抗生素包括甲氧苄啶-磺胺甲噁唑（10 例）和甲氧苄啶-磺胺甲噁唑联合多西环素（4 例）。未使用任何针对类鼻疽伯克霍尔德菌的静脉抗生素的患者接受了口服甲氧苄啶-磺胺甲噁唑（10 例）和甲氧苄啶-磺胺甲噁唑联合多西环素（1 例）治疗。未报告不良反应。我们能够随访 32 例患者，除 1 例患者报告可能复发外，所有患者均已康复。
