Visca P, Cazzola G, Petrucca A, Braggion C
Department of Biology, Università Roma Tre-Istituto Nazionale di Malattie Infettire "Lazzaro Spallanzani," Roma, Italia.
Clin Infect Dis. 2001 Jan;32(1):E15-6. doi: 10.1086/317528. Epub 2000 Dec 11.
In September 1997, a 25-year-old Italian woman with cystic fibrosis (CF) spent 3 weeks in Thailand. In August 1998, her pulmonary function rapidly declined, with productive cough and intermittent fever. Chest x-ray films revealed diffuse, small, patchy opacities in the upper lobes. Burkholderia pseudomallei (BP) was isolated from specimens of the patient's sputum and was identified by means of 16S rDNA sequencing. The diagnosis of melioidosis was serologically confirmed. Continuous therapy with ceftazidime and co-trimoxazole and maintenance with co-trimoxazole, doxycycline, and chloramphenicol resulted in eradication of BP. We present the issue of whether patients with CF represent a population particularly at risk for melioidosis.
1997年9月，一名25岁的患有囊性纤维化（CF）的意大利女性在泰国待了3周。1998年8月，她的肺功能迅速下降，伴有咳痰和间歇性发热。胸部X光片显示上叶有弥漫性、小片状的模糊阴影。从患者痰液标本中分离出类鼻疽伯克霍尔德菌（BP），并通过16S rDNA测序进行鉴定。血清学确诊为类鼻疽。使用头孢他啶和复方新诺明持续治疗，并使用复方新诺明、强力霉素和氯霉素维持治疗，最终根除了BP。我们提出囊性纤维化患者是否是特别易患类鼻疽的人群这一问题。
