大鼠松果体中的肿瘤抑制活性呈现出年周期节律。

Tumor-inhibiting activity in the rat pineal gland displays a circannual rhythm.

作者信息

Bartsch H, Bartsch C, Gupta D

机构信息

Department of Diagnostic Endocrinology, University Children's Hospital, Tübingen, Germany.

出版信息

J Pineal Res. 1990;9(3):171-8. doi: 10.1111/j.1600-079x.1990.tb00706.x.

DOI:10.1111/j.1600-079x.1990.tb00706.x

PMID:2082006

Abstract

The aim of this study was to investigate whether the tumor-inhibiting activity present in the rat pineal gland undergoes seasonal fluctuations as do other pineal substances. Crude ethanol extracts of rat pineal glands were tested for tumor-inhibiting activity in an in vitro microbioassay using human erythroleukemia cells which could not be inhibited by melatonin. Highest activity was detected in summer and least inhibition and even stimulation were observed in winter. There were no differences in activity between animals of different age, sex, or strain. Therefore, season seems to be the factor that exerts the most important influence on the content of tumor-inhibiting activity in the rat pineal gland. Correlation with seasonality in the occurrence of cancer is discussed.

摘要

本研究的目的是调查大鼠松果体中存在的肿瘤抑制活性是否会像其他松果体物质一样出现季节性波动。使用不能被褪黑素抑制的人红白血病细胞，通过体外微生物测定法对大鼠松果体的粗乙醇提取物进行肿瘤抑制活性测试。夏季检测到最高活性，而在冬季观察到最小抑制甚至刺激作用。不同年龄、性别或品系的动物在活性方面没有差异。因此，季节似乎是对大鼠松果体中肿瘤抑制活性含量产生最重要影响的因素。文中还讨论了与癌症发生季节性的相关性。