Rohner T J, Hannigan J D, Sanford E J
Urology. 1978 Apr;11(4):357-61. doi: 10.1016/0090-4295(78)90231-5.
Muscle strips from the bladder body and dome of normal and control dogs usually demonstrate a relaxing (beta-adrenergic) response to norepinephrine. After bladder outlet obstruction was caused by urethral constriction, all body muscle strips from 7 of 12 dogs (58 per cent) demonstrated contractile (alpha-adrenergic) responses to norepinephrine. Bladder base muscle strips continued to show alpha-adrenergic responses. Desensitization or decreased beta-adrenergic receptor activity may play a part in causing the low compliance and detrusor instability seen in patients with bladder outlet obstruction.
正常犬和对照犬膀胱体部和顶部的肌肉条通常对去甲肾上腺素表现出舒张（β-肾上腺素能）反应。在通过尿道狭窄造成膀胱出口梗阻后，12只犬中有7只（58%）的所有体部肌肉条对去甲肾上腺素表现出收缩（α-肾上腺素能）反应。膀胱底部肌肉条继续表现出α-肾上腺素能反应。脱敏或β-肾上腺素能受体活性降低可能在导致膀胱出口梗阻患者出现低顺应性和逼尿肌不稳定中起作用。
