Weh H J, Walter T A, Garbrecht M, Kremer B, Henne-Bruns D, Crone-Muenzebrock L S, Hossfeld D K
Department of Oncology/Hematology, University of Hamburg.
Onkologie. 1990 Oct;13(5):354-8. doi: 10.1159/000216795.
Fifty patients with locally far advanced or metastasizing gastric carcinoma were treated with 5-fluorouracil, adriamycin and methotrexate using a slightly modified FAMTX protocol. Complete remission was achieved in four (8%) patients, confirmed operatively, partial remission in 13 (26%) patients, two of these going into complete remission after operative removal of residual tumor. Median duration of remission for the six patients in complete remission was 21 months, for those in partial remission five months. Median survival for all 50 patients was seven months, for those in complete and partial remission 12 months, and for those without remission four months. These results indicate the possibility of a further improvement of treatment results in patients with metastasizing gastric carcinoma using this protocol of combined operation and chemotherapy.
五十例局部进展期或转移性胃癌患者采用稍作修改的FAMTX方案，接受氟尿嘧啶、阿霉素和甲氨蝶呤治疗。4例（8%）患者实现完全缓解，经手术确认；13例（26%）患者部分缓解，其中2例在手术切除残留肿瘤后实现完全缓解。6例完全缓解患者的中位缓解持续时间为21个月，部分缓解患者为5个月。50例患者的中位生存期为7个月，完全缓解和部分缓解患者为12个月，未缓解患者为4个月。这些结果表明，采用这种联合手术和化疗方案，转移性胃癌患者的治疗效果有可能进一步提高。
