Payungporn S, Panjaworayan N, Makkoch J, Poovorawan Y
Department of Biochemistry, Chulalongkorn University, Bangkok, Thailand.
Acta Virol. 2010;54(3):155-63. doi: 10.4149/av_2010_03_155.
The outbreak of the human pandemic influenza A (H1N1) has caused a considerable public concern. The aim of this review was to improve our understanding of this novel virus by analyzing the relationships between its molecular characteristics and pathogenic properties. Results of this analysis indicate that the human pandemic influenza A (H1N1) virus is a new re-assorted virus, which combines genetic materials from the avian flu (H1N1) virus, classical swine flu (H1N1) virus, human flu (H3N2) virus, and Eurasian swine flu (H1N1) virus. Analysis of the sequences for receptor-binding and cleavage sites of hemagglutinin (HA), stalk region of neuraminidase (NA), non-structural protein 1 (NS1), polymerase basic protein 2 (PB2), and polymerase basic protein 1 (PB1) suggested that (i) the human pandemic influenza A (H1N1) virus is a low virulent and low pathogenic virus, (ii) its replication is restricted to the cells of upper respiratory tract, so it does not lead to a systemic infection, (iii) it spreads among humans only, (iv) its replication could be inhibited by oseltamivir, zanamivir, interferon (IFN), and tumor necrosis factor alpha (TNF-alpha). A potential application of amantadine might be complicated by the drug-resistant virus strains.
甲型H1N1流感大流行的爆发引起了公众的广泛关注。本综述的目的是通过分析新型甲型H1N1流感病毒的分子特征与其致病特性之间的关系，加深我们对该病毒的了解。分析结果表明，甲型H1N1流感大流行病毒是一种新的重组病毒，它整合了来自禽流感（H1N1）病毒、经典猪流感（H1N1）病毒、人流感（H3N2）病毒和欧亚猪流感（H1N1）病毒的基因物质。对血凝素（HA）的受体结合和裂解位点、神经氨酸酶（NA）的柄部区域、非结构蛋白1（NS1）、聚合酶基本蛋白2（PB2）和聚合酶基本蛋白1（PB1）的序列分析表明：（i）甲型H1N1流感大流行病毒是一种低毒力和低致病性的病毒；（ii）其复制局限于上呼吸道细胞，因此不会导致全身感染；（iii）它仅在人与人之间传播；（iv）其复制可被奥司他韦、扎那米韦、干扰素（IFN）和肿瘤坏死因子α（TNF-α）抑制。金刚烷胺的潜在应用可能会因耐药病毒株而变得复杂。
