Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, USA.
Cancer Res. 2010 Oct 1;70(19):7360-4. doi: 10.1158/0008-5472.CAN-10-1208. Epub 2010 Sep 7.
Epithelial-mesenchymal transition (EMT) is a developmental program implicated in cancer progression and was the subject of the 2010 AACR meeting on the topic of EMT and Cancer Progression and Treatment held on February 28 to March 2 in Arlington, Virginia. A review of the involvement of EMT in gastrulation, organogenesis, carcinogenesis, and metastatic progression elucidated the overlap of EMT in these physiologic and pathologic conditions. Both novel and traditional markers of cells undergoing EMT were discussed and compared with features used to define cancer stem cells. Importantly, these defining characteristics of cells undergoing EMT were discussed in the context of therapeutic and prognostic developments.
上皮-间充质转化（EMT）是一个与癌症进展相关的发育程序，也是 2010 年美国癌症研究协会（AACR）关于 EMT 和癌症进展与治疗主题会议的主题，该会议于 2 月 28 日至 3 月 2 日在弗吉尼亚州阿灵顿举行。本文综述了 EMT 在原肠胚形成、器官发生、癌发生和转移进展中的作用，阐明了 EMT 在这些生理和病理条件下的重叠。讨论了 EMT 过程中细胞的新型和传统标志物，并与用于定义癌症干细胞的特征进行了比较。重要的是，还在治疗和预后发展的背景下讨论了 EMT 过程中细胞的这些定义特征。
