Rouhani S, Emmanouilidis E, Tran G, Durlach J, Payan C, Fermanian J, Manicom R, Soulairac A, Poenaru S
Département de Physiologie Humaine UFR Biomédicale, Paris, France.
Physiol Behav. 1990 Nov;48(5):637-40. doi: 10.1016/0031-9384(90)90203-g.
Waking and sleep states were studied in the alcohol-dependent rat after administration of ethanol (416 mg/kg/hr) by indwelling intragastric catheter (IGC) for 13 days. Electropolygraphic recordings performed for a total of 24 hr from the start of withdrawal were compared with those of control rats receiving water by IGC and showed 1) that rapid eye movement sleep was the most sensitive of the four vigilance states studied. A decrease was noted both for the total duration of recording and for the light period; 2) that nonactive wakefulness was the only vigilance state to show an inversion of percentages between the light and dark period; 3) that the light period was the best time for studying changes in vigilance states. Changes included increased percentages of active and nonactive wakefulness and decreased percentages of slow-wave and rapid eye movement sleep. This was due to a change in the number of episodes rather to a change in their mean duration. No significant change occurred during the dark period.
通过留置胃内导管（IGC）以416毫克/千克/小时的剂量给酒精依赖大鼠灌胃乙醇13天，研究其清醒和睡眠状态。从戒断开始共进行24小时的脑电图记录，并与通过IGC接受水的对照大鼠的记录进行比较，结果显示：1）快速眼动睡眠是所研究的四种警觉状态中最敏感的。记录的总时长和光照期均出现减少；2）非活动性清醒是唯一在光照期和黑暗期百分比出现反转的警觉状态；3）光照期是研究警觉状态变化的最佳时间。变化包括活动性和非活动性清醒的百分比增加，以及慢波睡眠和快速眼动睡眠的百分比减少。这是由于发作次数的变化而非平均时长的变化所致。黑暗期未发生显著变化。
