Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas, USA.
J Hypertens. 2010 Sep;28 Suppl 1:S7-12. doi: 10.1097/01.hjh.0000388488.51083.2b.
This survey summarizes the limited findings related to the ability of endogenously produced and exogenously administered melatonin to modify the response of the heart musculature to pathological situations that are normally accompanied by hypertrophy of the cardiomyocytes and alterations in cardiovascular physiology. Whereas melatonin did not reduce left ventricular hypertrophy in spontaneously hypertensive rats or in nitric oxide-deficient hypertension, it did have other beneficial effects, e.g. it curtailed oxidative damage to the heart that resulted in an attenuation of left ventricular fibrosis. In contrast to the findings in hypertensive rats, melatonin administration was effective in overcoming cardiac enlargement resulting from induced hyperthyroidism or chronic hypoxia exposure. In addition, in these situations, melatonin also conferred protection against free radical-mediated damage at the level of cardiomyocytes. Collectively, the results of the publications summarized herein along with numerous other published reports on other aspects of cardiovascular physiology indicate that, when damage to the heart is a result of free radicals, melatonin is clearly protective. This is not unexpected considering the now well documented potent antioxidative actions of both melatonin and its metabolites. In general, melatonin improves cardiovascular physiology and heart function.
本研究总结了内源性和外源性褪黑素对心肌肥厚和心血管生理改变的病理情况的反应的有限影响。虽然褪黑素不能减少自发性高血压大鼠或一氧化氮缺乏性高血压中的左心室肥厚，但它具有其他有益作用，例如，它减少了对心脏的氧化损伤，从而减轻了左心室纤维化。与高血压大鼠的发现相反，褪黑素的给药在克服由诱导性甲状腺功能亢进或慢性缺氧暴露引起的心脏增大方面是有效的。此外，在这些情况下，褪黑素还可以防止心肌水平的自由基介导的损伤。总的来说，本文总结的出版物的结果以及其他关于心血管生理学的其他方面的许多已发表报告表明，当心脏损伤是由自由基引起时，褪黑素显然是具有保护作用的。考虑到褪黑素及其代谢物现在已经有充分的抗氧化作用，这并不出人意料。一般来说，褪黑素可改善心血管生理和心脏功能。
