Institute of Molecular Medicine, Peking University, Beijing, 100871, People's Republic of China.
J Mol Med (Berl). 2010 Oct;88(10):987-91. doi: 10.1007/s00109-010-0675-5. Epub 2010 Sep 8.
Mitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes, including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential, and mtDNA stability. Dysfunction of mitochondrial dynamics has been implicated in various human diseases, especially in neurodegenerative diseases. Emerging evidence indicates that impaired expression of mitochondrial fusion proteins or their malfunction participates in oxidative stress-induced cardiovascular injury. This review will focus on recent advances of mitochondrial fusion in regulating various cellular processes in cardiovascular system.
线粒体是高度动态的细胞器，其形态不断变化，由融合和裂变事件调节。除了调节线粒体形态外，线粒体融合/裂变还参与基本的线粒体生物学过程，包括线粒体代谢、能量产生、呼吸、线粒体膜电位和 mtDNA 稳定性。线粒体动态功能障碍与各种人类疾病有关，特别是神经退行性疾病。新出现的证据表明，线粒体融合蛋白表达受损或功能障碍参与氧化应激诱导的心血管损伤。本综述将重点介绍线粒体融合在调节心血管系统中各种细胞过程中的最新进展。
