Department of Veterinary Biomedical Sciences, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada.
Cell Tissue Res. 2011 Jan;343(1):97-106. doi: 10.1007/s00441-010-1032-2. Epub 2010 Sep 8.
Mononuclear phagocytes are crucial components of the innate host defense system. Cells such as macrophages and monocytes phagocytose and process pathogens, produce inflammatory mediators, and link the innate and the adaptive immune systems. The role of innate immune receptors such as Toll-like receptors (TLRs) in the recognition of pathogens is critical for mounting a precise and targeted immune response. This review focuses attention on the development of monocytes and macrophages, various populations of macrophages, and the expression and function of TLRs on macrophages.
单核吞噬细胞是先天宿主防御系统的重要组成部分。巨噬细胞和单核细胞等细胞吞噬和处理病原体，产生炎症介质，并将先天免疫和适应性免疫系统联系起来。先天免疫受体（如 Toll 样受体（TLR））在识别病原体中的作用对于引发精确和靶向的免疫反应至关重要。本文重点关注单核细胞和巨噬细胞的发育、巨噬细胞的各种群体以及 TLR 在巨噬细胞上的表达和功能。
