Kumar Himanshu, Kawai Taro, Akira Shizuo
Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
Biochem Biophys Res Commun. 2009 Oct 30;388(4):621-5. doi: 10.1016/j.bbrc.2009.08.062. Epub 2009 Aug 15.
Toll-like receptors (TLRs) are evolutionarily conserved innate receptors expressed in various immune and non-immune cells of the mammalian host. TLRs play a crucial role in defending against pathogenic microbial infection through the induction of inflammatory cytokines and type I interferons. Furthermore, TLRs also play roles in shaping pathogen-specific humoral and cellular adaptive immune responses. In this review, we describe the recent advances in pathogen recognition by TLRs and TLR signaling.
Toll样受体（TLRs）是在哺乳动物宿主的各种免疫和非免疫细胞中表达的进化保守的天然受体。TLRs通过诱导炎性细胞因子和I型干扰素在抵御病原微生物感染中发挥关键作用。此外，TLRs在塑造病原体特异性体液和细胞适应性免疫反应中也发挥作用。在本综述中，我们描述了TLRs病原体识别和TLR信号传导方面的最新进展。
