Ma G, Ho S Y
Department of Physiology, Institute of Basic Medicine, Hebei Medical College.
Sheng Li Xue Bao. 1990 Jun;42(3):262-8.
Hemodynamic effects of renal mechano- and chemoreceptor activation and afferent renal nerve stimulation were observed in 39 anesthetized rabbits. The mean arterial pressure (MAP) and heart rate (HR) were decreased following elevation of ureteral pressure (13-22 mmHg), and retrograde perfusion of NaCl (1.0 mol/L) or KCl (0.15 mol/L) into pelvis via ureter route. The decrease in MAP was enhanced by sinoaortic denervation. HR, MAP, mesentery arterial perfusion pressure (MPP), hindlimb arterial perfusion pressure (HLPP), left ventricular pressure (LVP), left ventricular dp/dtmax (LV dp/dtmax), cardiac output (CO) and total peripheral resistance (TPR) were decreased during electrical stimulation of afferent renal nerve. By sinoaortic denervation, the aforementioned hemodynamic parameters, except HR, CO and TPR, were reduced more markedly by electric stimulation of afferent renal nerves. Therefore it appears that sinoaortic depressor reflex plays a buffer role in the cardiovascular responses to the stimulation of afferent renal nerves.
在39只麻醉兔中观察了肾机械感受器和化学感受器激活以及肾传入神经刺激的血流动力学效应。输尿管压力升高（13 - 22 mmHg）以及通过输尿管途径将NaCl（1.0 mol/L）或KCl（0.15 mol/L）逆行灌注到肾盂后，平均动脉压（MAP）和心率（HR）降低。去窦弓神经后，MAP的降低更为明显。肾传入神经电刺激期间，HR、MAP、肠系膜动脉灌注压（MPP）、后肢动脉灌注压（HLPP）、左心室压力（LVP）、左心室dp/dtmax（LV dp/dtmax）、心输出量（CO）和总外周阻力（TPR）均降低。去窦弓神经后，除HR、CO和TPR外，上述血流动力学参数在肾传入神经电刺激时降低更明显。因此，窦弓降压反射在对肾传入神经刺激的心血管反应中起缓冲作用。
