Sun S Y, Ho S Y
Sheng Li Xue Bao. 1989 Feb;41(1):1-9.
The Bezold-Jarisch reflex induced by intracoronary injection of nicotine (ICIN) of 5 micrograms/kg was studied in 40 anesthetized rabbits. Heart rate (HR), arterial blood pressure (ABP), left ventricular pressure (IVP), left ventricular dp/dt (LV dp/dt) and cardiac output (CO) were monitored and total peripheral resistance (TPR) was calculated. HR, ABP, LVP and LV dp/dt were decreased following ICIN. These inhibitory responses induced by ICIN were enhanced by sino-aortic denervation but abolished by bilateral vagotomy. Decreases in CO and TPR were also observed in response to ICIN. With the heart paced artificially to prevent bradycardia, the decreases in CO, TPR and ABP were still significant. Bilateral stellate ganglion section plus atropinization which abolished the decreases in HR and CO, did not significantly change the hypotensive response to ICIN. These data suggest that the hypotension evoked by Bezold-Jarisch reflex in rabbit is largely due to the decreases in TPR and partially caused by the decrease in CO.
在40只麻醉兔中研究了冠状动脉内注射5微克/千克尼古丁（ICIN）诱发的贝佐尔德-雅里什反射。监测心率（HR）、动脉血压（ABP）、左心室压力（IVP）、左心室dp/dt（LV dp/dt）和心输出量（CO），并计算总外周阻力（TPR）。ICIN后HR、ABP、LVP和LV dp/dt降低。ICIN诱导的这些抑制反应通过窦主动脉去神经增强，但通过双侧迷走神经切断术消除。对ICIN的反应还观察到CO和TPR降低。在人工起搏心脏以防止心动过缓时，CO、TPR和ABP的降低仍然显著。双侧星状神经节切断术加阿托品化消除了HR和CO的降低，但对ICIN的降压反应没有显著改变。这些数据表明，兔贝佐尔德-雅里什反射诱发的低血压主要是由于TPR降低，部分是由CO降低引起的。
