Dion R, Lavenne-Pardonge E, Scheiff J M, Verhelst R, Baele P, Moriau M
Cliniques Universitaires St-Luc (U.C.L.), Brussels, Belgium.
Thromb Res Suppl. 1990;12:81-6. doi: 10.1016/0049-3848(90)90443-g.
Patency rates of coronary artery saphenous vein bypass grafts can be as low as 50% in the first year after surgery. Of these occlusions, 70% can be attributed to mural thrombus formation. Improvements in surgical handling techniques and in preservation media have improved patency rates, as has the introduction of perioperative antiplatelet therapy. The authors describe a novel preservation medium consisting of heparinized blood from the patient, papaverine and dipyridamole. This medium enhances prostacyclin production and maintains endothelial integrity in preserved saphenous vein segments.
冠状动脉大隐静脉旁路移植术的通畅率在术后第一年可能低至50%。在这些闭塞病例中，70%可归因于壁血栓形成。手术操作技术和保存介质的改进提高了通畅率，围手术期抗血小板治疗的引入也起到了同样的作用。作者描述了一种新型保存介质，它由患者的肝素化血液、罂粟碱和双嘧达莫组成。这种介质可增强前列环素的产生，并维持保存的大隐静脉段的内皮完整性。
