Kazakova O M, Khokhrina N T, Uzbekov M G
Tsitologiia. 1990;32(10):1006-9.
A histochemical investigation was made of aminopeptidase activities using L-leucine-beta-naphthylamide and D, L-alanine-beta-naphthylamine as respective substrates in the rat's sensomotor cortex neurons during the period of ethanol withdrawal after a prolonged alcohol intoxication. Alcohol intoxication of the rat continued for 8 months. Different dynamics of aminopeptidase activities was shown depending on the substrate used during ethanol withdrawal. The results are discussed from the point of view of the existence of multiple forms of aminopeptidase in the brain and of their involvement in protein metabolism in pathological states.
在大鼠长期酒精中毒后的戒断期，以L-亮氨酸-β-萘酰胺和D，L-丙氨酸-β-萘胺分别作为底物，对感觉运动皮层神经元中的氨肽酶活性进行了组织化学研究。大鼠酒精中毒持续8个月。结果表明，在酒精戒断期间，根据所使用的底物不同，氨肽酶活性呈现出不同的动态变化。从大脑中存在多种形式的氨肽酶及其在病理状态下参与蛋白质代谢的角度对结果进行了讨论。
