Influence of preincubation on the development of the inhibition of protein synthesis in extracts from interferon-treated mouse L cells. Action on tRNA.
作者信息
Falcoff R, Falcoff E, Sanceau J, Lewis J A
出版信息
Virology. 1978 May 15;86(2):507-15. doi: 10.1016/0042-6822(78)90089-2.
PMID:208258
Abstract
摘要
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Influence of preincubation on the development of the inhibition of protein synthesis in extracts from interferon-treated mouse L cells. Action on tRNA.预孵育对经干扰素处理的小鼠L细胞提取物中蛋白质合成抑制作用发展的影响。对tRNA的作用。
Virology. 1978 May 15;86(2):507-15. doi: 10.1016/0042-6822(78)90089-2.
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Dual action of double-stranded RNA inhibiting protein synthesis in extracts of interferon-treated mouse L cells. Translation is impaired at the level of initiation and by mRNA degradation.双链RNA在经干扰素处理的小鼠L细胞提取物中抑制蛋白质合成的双重作用。翻译在起始水平受到损害，并通过信使核糖核酸降解。
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Interferon treatment inhibits Mengo RNA and haemoglobin mRNA translation in cell-free extracts of L cells.干扰素治疗可抑制L细胞无细胞提取物中 Mengo RNA和血红蛋白mRNA的翻译。
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Interferon treatment of Ehrlich ascites tumor cells: effects on exogenous mRNA translation and tRNA inactivation in the cell extract.干扰素对艾氏腹水癌细胞的治疗：对细胞提取物中外源mRNA翻译和tRNA失活的影响。
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Mechanism of interferon action. Interferon-mediated inhibition of reovirus mRNA translation in the absence of detectable mRNA degradation but in the presence of protein phosphorylation.干扰素作用机制。在未检测到mRNA降解但存在蛋白质磷酸化的情况下，干扰素介导的呼肠孤病毒mRNA翻译抑制。
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Selective inhibition of viral protein accumulation in interferon-treated cells; nondiscriminate inhibition of the translation of added viral and cellular messenger RNAs in their extracts.在干扰素处理的细胞中对病毒蛋白积累的选择性抑制；对其提取物中添加的病毒和细胞信使核糖核酸翻译的非特异性抑制。
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A protein synthesizing system from interferon-treated cells that discriminates between cellular and viral messenger RNAs.一种来自经干扰素处理的细胞的蛋白质合成系统，该系统能够区分细胞信使核糖核酸和病毒信使核糖核酸。
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Kinetics of messenger accumulation coding for IFN gamma, related to modifications in the poly(A) RNA population of activated human lymphocytes.编码干扰素γ的信使积累动力学，与活化的人淋巴细胞多聚腺苷酸RNA群体的变化有关。
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The interferon renaissance: molecular aspects of induction and action.干扰素的复兴：诱导与作用的分子层面
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Mechanism of interferon action: phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase.干扰素作用机制：在经干扰素处理的人细胞中，核糖体相关激酶使蛋白质合成起始因子eIF-2磷酸化，该激酶的加工位点特异性类似于血红素调节的兔网织红细胞激酶。
Proc Natl Acad Sci U S A. 1979 Feb;76(2):600-4. doi: 10.1073/pnas.76.2.600.
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An interferon-induced phosphodiesterase degrading (2'-5') oligoisoadenylate and the C-C-A terminus of tRNA.一种干扰素诱导的磷酸二酯酶，可降解（2'-5'）寡聚异腺苷酸及tRNA的C-C-A末端。
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