产超广谱β-内酰胺酶肠杆菌科细菌

[Extended-spectrum beta-lactamase producing-enterobacteriaceae].

作者信息

Doit C, Mariani-Kurkdjian P, Bingen E

机构信息

Service de bactériologie, Université Paris-Diderot, Hôpital Robert Debré, 48, Boulevard Sérurier, 75935 Paris cedex 19, France.

出版信息

Arch Pediatr. 2010 Sep;17 Suppl 4:S140-4. doi: 10.1016/S0929-693X(10)70915-5.

DOI:10.1016/S0929-693X(10)70915-5

PMID:20826322

Abstract

Extended-spectrum beta-lactamase (ESBLs) are defined as β-lactamase capable of hydrolyzine oximino-cephalosporins and aztreonam and are encoded by mobile genes. The most frequently encountered ESBLs belong to the CTX-M, SHV, and TEM families. ESBLs were found first in Klebsiella pneumonia and then predominantly in E. coli. The incidence of patients with ESBLs E. coli increase since 2000 in Robert Debré Hospital. They were responsible of cystitis or pyelopnephritis and rarely of materno-foetal infections or neonatal meningitis. These strains were susceptible to colimycin, carbapenems and fosfomycin.

摘要

超广谱β-内酰胺酶（ESBLs）被定义为能够水解肟基头孢菌素和氨曲南的β-内酰胺酶，由可移动基因编码。最常见的ESBLs属于CTX-M、SHV和TEM家族。ESBLs最早在肺炎克雷伯菌中发现，随后主要在大肠杆菌中发现。自2000年以来，罗伯特·德布雷医院中携带ESBLs的大肠杆菌患者的发病率有所增加。它们可导致膀胱炎或肾盂肾炎，很少引起母婴感染或新生儿脑膜炎。这些菌株对黏菌素、碳青霉烯类和磷霉素敏感。