Aubin F, Manteaux A
Départment of Immunology, University of Texas, M.D. Anderson Cancer Center, Houston.
Ann Dermatol Venereol. 1990;117(12):931-6.
The molecular aspects of the mode of action of psoralens is not clearly understood since two types of reactions may occur simultaneously and independently of each other, when the psoralen-treated skin is exposed to ultraviolet A radiation. Type 1 is an oxygen-independent reaction, leading directly to photoaddition of psoralen to pyrimidine bases of DNA, and type 2 is an indirect oxygen-dependent reaction involving the generation of reactive oxygen species. Thus, the psoralens can damage the cell membranes, the cytoplasmic constituents and the cell nuclei resulting in the observed phototoxic effects. The molecular mechanisms underlying the generation of free radicals and DNA damages are described, and are related to the two classes of psoralens.
补骨脂素作用方式的分子机制尚未完全明确，因为当用补骨脂素处理过的皮肤暴露于紫外线A辐射时，两种类型的反应可能同时且相互独立地发生。类型1是不依赖氧的反应，直接导致补骨脂素与DNA的嘧啶碱基发生光加成反应，而类型2是间接的依赖氧的反应，涉及活性氧的产生。因此，补骨脂素可损伤细胞膜、细胞质成分和细胞核，从而导致观察到的光毒性效应。文中描述了自由基产生和DNA损伤的分子机制，并将其与两类补骨脂素联系起来。
