Paterson Paul, Sher Haroon, Wylie Faye, Wallace Shirley, Crawford Anne, Sood Vikas, Gillgrass Toby, Ray Arup, Devlin Mark
Cleft Palate Craniofac J. 2011 Sep;48(5):608-13. doi: 10.1597/09-238. Epub 2010 Sep 8.
To determine the proportion of children with cleft lip and/or cleft palate diagnosed prenatally between 1999 and 2008 in those referred for treatment to the Royal Hospital for Sick Children in Glasgow, Scotland (RHSC); and to compare the percentage prenatally diagnosed in 2008 versus other cleft treatment centers in the U.K.
A retrospective study was performed using medical records of the 459 cleft patients born and referred to RHSC between 1999 and 2008. Comparable data for year 2008 were requested from other U.K. units.
For the period studied, the percentage of all clefts diagnosed prenatally was 15%. This rose to 28% when only the cases of cleft lip with or without cleft palate (CL ± P) were considered. An increase was seen in prenatal detection of CL ± P from 11% in 1999 to 50% in 2008 (p = .011). Two of the six U.K. units that responded had a significantly higher percentage of CL ± P cases diagnosed prenatally compared with RHSC in 2008 (p < .05).
The percentage of CL ± P cases diagnosed prenatally in this study is consistent with the literature and increased between 1999 and 2008. Routine ultrasound anomaly scanning is shown to significantly improve detection rates compared with scanning of high-risk pregnancies only. Cases of CL ± P where the alveolus or the palate is involved have significantly higher detection rates than those involving only the lip.
确定1999年至2008年间在苏格兰格拉斯哥皇家儿童医院（RHSC）接受治疗的唇裂和/或腭裂患儿中，产前诊断出的比例；并比较2008年与英国其他腭裂治疗中心产前诊断出的百分比。
采用回顾性研究，使用1999年至2008年间出生并转诊至RHSC的459例腭裂患者的病历。向英国其他单位索取了2008年的可比数据。
在所研究的时间段内，产前诊断出的所有腭裂比例为15%。仅考虑唇裂伴或不伴腭裂（CL±P）病例时，这一比例升至28%。CL±P的产前检测从1999年的11%增至2008年的50%（p = 0.011）。回复的六个英国单位中有两个单位在2008年产前诊断出的CL±P病例百分比显著高于RHSC（p < 0.05）。
本研究中产前诊断出的CL±P病例百分比与文献一致，且在1999年至2008年间有所增加。与仅对高危妊娠进行扫描相比，常规超声异常扫描显示能显著提高检测率。涉及牙槽或腭部的CL±P病例的检测率显著高于仅涉及唇部的病例。
