Department of Basic Sciences in Health, Faculty of Medical Sciences, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil.
J Med Food. 2010 Oct;13(5):1161-6. doi: 10.1089/jmf.2009.0247.
Echinodorus macrophyllus leaf has been used in Brazilian folk medicine to treat inflammatory conditions and kidney dysfunctions. The present study evaluated the effects of leaf ethanolic extract from E. macrophyllus (EEEm) in acute and subchronic models of inflammation. The EEEm was found to cause significant and potent inhibition of carrageenan- and dextran-induced paw edema in rats and marked decreases in the exudate volume and leukocyte migration in rats with carrageenan-induced pleurisy, the vascular permeability increase induced by intraperitoneal acetic acid, and the croton oil-induced topical ear edema in mice. On the other hand, the EEEm was not active in the test model of cotton pellet-induced granuloma in rats. Phytochemical analysis with E. macrophyllus leaves revealed the presence of triterpenoids, steroids, flavones, flavonols, and xanthones. Two flavonoids were isolated from the ethyl acetate fraction and identified as isovitexin and vitexin. Our results support the traditional use of E. macrophyllus leaves in the treatment of acute inflammatory conditions.
大水榕的叶子在巴西民间医学中被用于治疗炎症和肾脏功能障碍。本研究评估了大水榕叶乙醇提取物（EEEm）在急性和亚慢性炎症模型中的作用。EEEm 显著且强效地抑制了角叉菜胶和葡聚糖诱导的大鼠足肿胀，并显著减少了角叉菜胶诱导的胸膜炎大鼠渗出物体积和白细胞迁移、腹腔内醋酸诱导的血管通透性增加以及小鼠巴豆油诱导的耳部水肿。另一方面，EEEm 在大鼠棉球肉芽肿诱导模型中不活跃。对大水榕叶的植物化学分析表明存在三萜类、甾体、类黄酮、黄酮醇和黄烷酮。从乙酸乙酯部分分离出两种类黄酮，并鉴定为异荭草苷和荭草苷。我们的结果支持大水榕叶在治疗急性炎症中的传统用途。
