Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu 44618, Nepal.
Biomed Res Int. 2021 Oct 4;2021:1636816. doi: 10.1155/2021/1636816. eCollection 2021.
Respiratory inflammation is caused by an air-mediated disease induced by polluted air, smoke, bacteria, and viruses. The COVID-19 pandemic is also a kind of respiratory disease, induced by a virus causing a serious effect on the lungs, bronchioles, and pharynges that results in oxygen deficiency. Extensive research has been conducted to find out the potent natural products that help to prevent, treat, and manage respiratory diseases. Traditionally, wider floras were reported to be used, such as , , , , but only some of the potent compounds from some of the plants have been scientifically validated. Plant-derived natural products such as colchicine, zingerone, forsythiaside A, mangiferin, glycyrrhizin, curcumin, and many other compounds are found to have a promising effect on treating and managing respiratory inflammation. In this review, current clinically approved drugs along with the efficacy and side effects have been studied. The study also focuses on the traditional uses of medicinal plants on reducing respiratory complications and their bioactive phytoconstituents. The pharmacological evidence of lowering respiratory complications by plant-derived natural products has been critically studied with detailed mechanism and action. However, the scientific validation of such compounds requires clinical study and evidence on animal and human models to replace modern commercial medicine.
呼吸道炎症是由空气污染、烟雾、细菌和病毒引起的空气传播疾病引起的。COVID-19 大流行也是一种呼吸道疾病，由病毒引起，对肺部、细支气管和咽部造成严重影响，导致缺氧。已经进行了广泛的研究，以寻找有助于预防、治疗和管理呼吸道疾病的有效天然产物。传统上，报道了更广泛的植物群被用于治疗，例如， ， ， ， ，但只有一些植物的有效化合物已经得到了科学验证。从植物中提取的天然产物，如秋水仙碱、生姜素、连翘苷 A、芒果苷、甘草酸、姜黄素和许多其他化合物，被发现对治疗和管理呼吸道炎症有很好的效果。在这篇综述中，研究了目前临床批准的药物及其疗效和副作用。该研究还侧重于药用植物在减少呼吸道并发症及其生物活性植物成分方面的传统用途。还对植物源性天然产物通过降低呼吸并发症的药理作用进行了批判性研究，包括详细的机制和作用。然而，这些化合物的科学验证需要在动物和人体模型上进行临床研究和证据，以替代现代商业药物。
