Department of Life Science and Biotechnology, Jadavpur University, Kolkata, West Bengal, India.
Eur J Pharmacol. 2010 Dec 1;648(1-3):6-14. doi: 10.1016/j.ejphar.2010.08.045. Epub 2010 Sep 7.
The phenothiazine group of drugs has long been known as antipsychotic drugs and previously it was extensively used for the treatment of anxiety. Several pieces of evidence have shown that they interfere with a variety of cellular processes and in vitro can interact with biomolecules like DNA, proteins etc. Recent reports have also revealed some new properties like antimicrobial, antiprionic, anticancerous activities of certain members of the phenothiazine group. Appropriate clinical application of phenothiazines can be developed in the future after gaining a comprehensive knowledge about their function. Information relating to the toxic and beneficial effects of these drugs has been discussed in this review.
吩噻嗪类药物长期以来一直被称为抗精神病药物，以前曾广泛用于治疗焦虑症。有几项证据表明，它们会干扰多种细胞过程，并且在体外可以与 DNA、蛋白质等生物分子相互作用。最近的报告还揭示了吩噻嗪类药物的某些成员的一些新特性，如抗微生物、抗朊病毒、抗癌活性。在全面了解其功能后，未来可以开发出吩噻嗪类药物的适当临床应用。本文综述了这些药物的毒性和有益作用的相关信息。
