The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
FEBS Lett. 2010 Dec 15;584(24):4858-64. doi: 10.1016/j.febslet.2010.09.002. Epub 2010 Sep 7.
Dynamic rearrangements of the actin cytoskeleton, following T-cell antigen receptor (TCR) engagement, provide the structural matrix and flexibility to enable intracellular signal transduction, cellular and subcellular remodeling, and driving effector functions. Recently developed cutting-edge imaging technologies have facilitated the study of TCR signaling and its role in actin-dependent processes. In this review, we describe how TCR signaling cascades induce the activation of actin regulatory proteins and the formation of actin networks, and how actin dynamics is important for T-cell homeostasis, activation, migration, and other effector functions.
细胞骨架的动态重排，紧随 T 细胞抗原受体（TCR）的结合，提供了结构基质和灵活性，从而实现细胞内信号转导、细胞和亚细胞重塑以及效应功能的驱动。最近开发的前沿成像技术促进了 TCR 信号及其在依赖于肌动蛋白的过程中的作用的研究。在这篇综述中，我们描述了 TCR 信号级联如何诱导肌动蛋白调节蛋白的激活和肌动蛋白网络的形成，以及肌动蛋白动力学如何对 T 细胞的动态平衡、激活、迁移和其他效应功能重要。
